An estimation method of protein networks for fluctuation cell cycle

• Project/Area Number: 23760382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Control engineering
• Research Institution: Utsunomiya University
• Principal Investigator: AZUMA Takehito 宇都宮大学, 工学研究科, 准教授 (60308179)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: システムバイオロジー / システム制御 / 細胞周期 / タンパク質ネットワーク / システム科学 / システム同定 / タンパク質ネットワーク推定

Research Abstract

This research proposes an approach to estimate 6-dimensilnal protein networks for cell cycle based on the least-squares method and demonstrates the efficacy on computer simulation. Moreover estimation problems for fluctuation cell cycle are experimented on computer simulation. Robustness of estimated 6-dimensional protein networks is verified by using periodic sensitivity analysis.

Research Products

• [Journal Article] Robustness Analysis of10-dimensional Cell Cycle Systems based on Periodic Sensitivity (2012)
  • Author(s): Takehito Azuma
  • Journal Title: Proceedings of the 6th International Conference on Sensing Technology Volume: Vol. 1 Pages: 506-511
  • Peer Reviewed
• [Journal Article] Robustness Analysis of 10-dimensional Cell Cycle Systems based on Periodic Sensitivity (2012)
  • Author(s): Takehito Azuma
  • Journal Title: The 6th International Conference on Sensing Technology Volume: 1 Pages: 506-511
  • Peer Reviewed
• [Journal Article] An approach to estimating protein networks of cell cycle based on least-squares methods for periodic Signals (2011)
  • Author(s): Takehito Azuma, Mayumi Ito, Shuichi Adachi
  • Journal Title: Proceeding of2011 Fifth International Conference onSensing Technology Volume: Vol. 1 Pages: 484-489
  • Peer Reviewed
• [Journal Article] Estimation of Protein Networks Based on Least-squares Method for Pseudo Periodic Signals (2011)
  • Author(s): Noriko Takahashi, Takehito Azuma, Mayumi Ito, Shuichi Adachi
  • Journal Title: Proceedings of the13th IASTED International Conference onIntelligent Systems and Control Volume: Vol. 1 Pages: 48-54
  • Peer Reviewed
• [Journal Article] A Least-squares Method for Periodic Signals of Cell Cycle to Estimate Protein Networks (2011)
  • Author(s): Takehito Azuma, Noriko Takahashi, Mayumi Ito, Shuichi Adachi
  • Journal Title: Proceedings of the 8th Asian Control Conference Pages: 482-487
  • Peer Reviewed
• [Journal Article] An approach to estimating protein networks of cell cycle based on least-squares methods for periodic signals (2011)
  • Author(s): Takehito Azuma, Mayumi Ito, Shuichi Adachi
  • Journal Title: Proceeding of 2011 Fifth International Conference on Sensing Technology Volume: 1 Pages: 484-489
  • Peer Reviewed
• [Journal Article] Estimation of Protein Networks Based on Least-squares Method for Pseudo Periodic Signals (2011)
  • Author(s): Noriko Takahashi, Takehito Azuma, Mayumi Ito, Shuichi Adachi
  • Journal Title: Proceedings of the 13th IASTED International Conference on Intelligent Systems and Control Volume: 1 Pages: 48-54
  • Peer Reviewed
• [Journal Article] Cdh1とCdc20タンパク質の結合を考慮した9次元細胞周期システムのロバストネス解析 (2011)
  • Author(s): 伊藤まゆ美，東 剛人，高橋 知子，足立修一
  • Journal Title: 第11回制御部門大会 Volume: 1
• [Journal Article] 疑似周期信号に対する最小二乗法を用いた細胞周期のタンパク質ネットワークの推定 (2011)
  • Author(s): 高橋知子，東 剛人，足立修一
  • Journal Title: 第11回制御部門大会 Volume: 1
• [Journal Article] セルサイクルにおけるCdc20の結合を考慮したタンパク質ネットワークのロバストネス解析 (2011)
  • Author(s): 伊藤まゆ美，東 剛人，足立修一
  • Journal Title: 第40回制御理論シンポジウム Volume: 1 Pages: 9-14
• [Presentation] Robustness Analysis of10-dimensional Cell Cycle Systems based on Periodic Sensitivity (2012)
  • Author(s): Takehito Azuma
  • Organizer: The 6th International Conference on Sensing Technology
  • Place of Presentation: Kolkata(India)
  • Year and Date: 2012-12-18
• [Presentation] An approach to estimating protein networks of cell cycle based on least-squares methods for periodic Signals (2011)
  • Author(s): Takehito Azuma, Mayumi Ito, Shuichi Adachi
  • Organizer: The fifth International Conference on Sensing Technology
  • Place of Presentation: Palmerston North(New Zealand)
  • Year and Date: 2011-12-01
• [Presentation] セルサイクルにおけるCdc20の結合を考慮したタンパク質ネットワークのロバストネス解析 (2011)
  • Author(s): 伊藤まゆ美,東剛人,足立修一
  • Organizer: 第40回制御理論シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-26
• [Presentation] Estimation of Protein Networks Based on Least-squares Method for Pseudo Periodic Signals (2011)
  • Author(s): Noriko Takahashi, Takehito Azuma, Mayumi Ito, Shuichi Adachi
  • Organizer: The 13th IASTED International Conference onIntelligent Systems and ControlJuly
  • Place of Presentation: Cambridge(United Kingdom)
  • Year and Date: 2011-07-11
• [Presentation] A Least- squares Method for Periodic Signals of Cell Cycle to Estimate Protein Networks (2011)
  • Author(s): Takehito Azuma, Noriko Takahashi, Mayumi Ito, Shuichi Adachi
  • Organizer: The 8th Asian Control Conference
  • Place of Presentation: Kaohsiung(Taiwan)
  • Year and Date: 2011-05-15
• [Presentation] An approach to estimating protein networks of cell cycle based on least-squares methods for periodic signals (2011)
  • Author(s): Takehito Azuma
  • Organizer: Fifth International Conference on Sensing Technology
  • Place of Presentation: Palmerston North
• [Presentation] Estimation of Protein Networks Based on Least-squares Method for Pseudo Periodic Signals (2011)
  • Author(s): Takehito Azuma
  • Organizer: 13th IASTED International Conference on Intelligent Systems and Control
  • Place of Presentation: Cambridge
• [Presentation] A Least-squares Method for Periodic Signals of Cell Cycle to Estimate Protein Networks (2011)
  • Author(s): Takehito Azuma
  • Organizer: 8th Asian Control Conference
  • Place of Presentation: Kaohsiung