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Nonlinear Spatio-Temporal Dynamics of Electroporation: Modeling, Analysis, and Control

Research Project

Project/Area Number 23760390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Control engineering
Research InstitutionKyoto University

Principal Investigator

SUSUKI Yoshihiko  京都大学, 大学院・工学研究科, 講師 (40402961)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsエレクトロポレーション / 非線形動力学 / 制御技術 / 制御工学 / バイオテクノロジー / 電気機器工学 / マイクロマシン / 流体工学
Research Abstract

The goal of this research was to establish a control technology of electroporation in a single cell. Towards the goal, I analyzed nonlinear spatio-temporal dynamics emerging in electroporation of a single cell and synthesized a control protocol for regulating the electroporation. A new control protocol using amplitude-modulated electric fields for regulating the cell membrane permittivity was developed and demonstrated in numerical simulations.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] 振幅変調電界によるエレクトロポレーションの一検討2013

    • Author(s)
      薄 良彦
    • Organizer
      電子情報通信学会技術報告
    • Place of Presentation
      福岡
    • Year and Date
      2013-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] A numerical study on electroporation by amplitude -modulated electric field2013

    • Author(s)
      Yoshihiko Susuki
    • Organizer
      Proceedings of the 2013 International Symposium on Nonlinear Theory and its Applications (NOLTA2013)
    • Place of Presentation
      Santa Fe, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 振幅変調電界を用いたエレクトロポレーションの一検討2013

    • Author(s)
      薄 良彦
    • Organizer
      電子情報通信学会 非線形問題研究会
    • Place of Presentation
      福岡大学
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www-lab23.kuee.kyoto-u.ac.jp/susuki

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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