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Preparation of bioresorbable bone-repairing materials which promote bone regeneration

Research Project

Project/Area Number 23760630
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Inorganic materials/Physical properties
Research InstitutionTohoku University

Principal Investigator

KAMITAKAHARA Masanobu  東北大学, 大学院・環境科学研究科, 准教授 (80362854)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords機能性セラミックス / 骨修復 / 骨再生 / リン酸カルシウム
Research Abstract

We aimed the preparation of bioresorbable bone-repairing materials which promote bone regeneration. We prepared silicate-containing tricalcium phosphate (TCP) and revealed that the sintered silicate-containing TCP showed higher apatite-forming ability in a simulated body fluid than the silicate-free TCP. When the compact of silicate-containingTCP powder was hydrothermally treated, the Ca-deficient HA ceramic composed of rod-shaped particles was obtained. On the other hand, we revealed that the dissolution rate of the Ca-deficient in the acidic buffer solution increased with the Ca-deficiency degree. We established the synthesis process and evaluated the basic materials.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Characterization and In Vitro Evaluation of Silicate-Containing Tricalcium Phosphate Prepared through Wet Chemical Process2013

    • Author(s)
      Masanobu Kamitakahara, Shota Umemoto, Koji Ioku
    • Journal Title

      Key Engineering Materials

      Volume: 529-530巻 Pages: 105-108

    • DOI

      10.4028/www.scientific.net/kem.529-530.105

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and in vitro evaluation of hydroxyapatite with controlled morphology2012

    • Author(s)
      M.Kamitakahara, T.Saito, K.Ioku
    • Journal Title

      Journal of Physics : Conference Series

      Volume: 339 Issue: 1 Pages: 12002-12002

    • DOI

      10.1088/1742-6596/339/1/012002

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 柱状粒子からなるCa欠損水酸アパタイトの特性評価2012

    • Author(s)
      蛭子貴文、上高原理暢、井奥洪二
    • Organizer
      第16回生体関連セラミックス討論会
    • Place of Presentation
      千葉工業大学
    • Year and Date
      2012-11-30
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Characterization and In Vitro Evaluation of Silicate-Containing Tricalcium Phosphate Prepared through Wet Chemical Process2012

    • Author(s)
      M. Kamitakahara, S. Umemoto, K. Ioku
    • Organizer
      24th Symposium and Annual Meeting of International Society for Ceramics in Medicine (Bioceramics 24)
    • Place of Presentation
      九州大学
    • Year and Date
      2012-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Behavior of Osteoblast-like Cells on Porous Hydroxyapatite Ceramics Prepared through Hydrothermal Process2012

    • Author(s)
      Masanobu Kamitakahara, Yuika Uno, Koji Ioku
    • Organizer
      International Conference on Traditional and Advanced Ceramics (ICTA2012)
    • Place of Presentation
      The Emerald Hotel, バンコク, タイ
    • Year and Date
      2012-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 柱状粒子からなるCa欠損水酸アパタイトペレットの溶解挙動の検討2012

    • Author(s)
      蛭子貴文、上高原理暢、井奥洪二
    • Organizer
      資源素材学会東北支部平成24年度春季大会
    • Place of Presentation
      東北大学
    • Year and Date
      2012-06-22
    • Related Report
      2012 Final Research Report
  • [Presentation] リン酸カルシウムの特性を活用した高機能人工骨の創製2012

    • Author(s)
      上高原理暢
    • Organizer
      日本セラッミクス協会2012年年会
    • Place of Presentation
      日京都大学
    • Year and Date
      2012-03-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Behavior of Osteoblast-like Cells on Porous Hydroxyapatite Ceramics Prepared through Hydrothermal Process2012

    • Author(s)
      Masanobu Kamitakahara, Yuika Uno, Koji Ioku
    • Organizer
      International Conference on Traditional and Advanced Ceramics (ICTA2012)
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization and In Vitro Evaluation of Silicate-Containing Tricalcium Phosphate Prepared through Wet Chemical Process2012

    • Author(s)
      M. Kamitakahara, S. Umemoto, K. Ioku
    • Organizer
      24th Symposium and Annual Meeting of International Society for Ceramics in Medicine (Bioceramics 24)
    • Place of Presentation
      Kyushu University
    • Related Report
      2012 Annual Research Report
  • [Presentation] リン酸カルシウムの特性を活用した高機能人工骨の創製2012

    • Author(s)
      上高原理暢
    • Organizer
      日本セラミックス協会2012年年会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ケイ酸含有量の異なるリン酸三カルシウムの作製および評価2011

    • Author(s)
      梅本奨大、上高原理暢、井奥洪二
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] ケイ酸含有量の異なるリン酸三カルシウムの作製および評価2011

    • Author(s)
      梅本奨大,上高原理暢,井奥洪二
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] 柱状粒子からなるCa欠損水酸アパタイトペレットの溶解挙動の検討

    • Author(s)
      蛭子貴文, 上高原理暢, 井奥洪二
    • Organizer
      資源素材学会東北支部平成24年度春季大会
    • Place of Presentation
      東北大学片平キャンパスキャンパス
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://ehtp.kankyo.tohoku.ac.jp/ioku/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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