| Project/Area Number |
23760745
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Tohoku University |
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Principal Investigator |
INO Kosuke 東北大学, 環境科学研究科, 助教 (00509739)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | バイオセンサー / 電気化学分析 / バイオMEMS / 微小電極アレイ / 細胞解析 / マイクロ・ナノシステム / 電気化学イメージング / 分析化学 / 電気化学 / 生体関連化学 / 微小電極 / 電気化学測定 / 網羅的検出法 / 3次元培養細胞 / レドックスサイクリング / Lab on a chip / 新規測定システム |
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| Research Abstract |
In this study, we developed a novel electrochemical system and device for cell analysis. The system is based on redox cycling, which is used for signal amplification and addressable detection. By using the electrochemical system, many electrochemical sensors were successfully incorporated into a small chip device. Microwells were also placed onto each sensor for trapping cells. We developed several kinds of devices containing interdigitated array electrodes, ring-ring electrodes, ring-disk electrodes, and applied the devices for bioassays. By using the devices, cell activity and enzyme activity were successfully evaluated, indicating that the system and device are useful for cell analysis.
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