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Development of capillary-like network for creating three-dimensional tissues

Research Project

Project/Area Number 23760752
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biofunction/Bioprocess
Research InstitutionKagoshima University (2012)
Kyushu University (2011)

Principal Investigator

TAKEI Takayuki  鹿児島大学, 大学院・理工学研究科, 准教授 (90468059)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords毛細血管 / ヒドロゲル / ファイバー / 再生医療
Research Abstract

Poly(methyl methacrylate)(PMMA)microfibers of approximately 10μm in diameter were prepared using wet spinning technique. The microfibers were embedded in agarose gel and dissolved specifically, resulting in formation of capillary-like network in the gel. The gel was freeze-dried and hepatoblastomawas seeded into the sponge-like gel. Then, the sponge was coated with agarose gel. Culture medium was perfused into the capillary-like network in the sponge. Albumin productivity of the sponge with perfusion of medium was higher than that without medium perfusion.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Injectable and biodegradable sugar beet pectin/gelatin hydrogels for biomedical application2013

    • Author(s)
      Takayuki Takei
    • Journal Title

      Journal of Biomaterials Science, Polymer Edition

      Volume: in press Issue: 11 Pages: 1333-1342

    • DOI

      10.1080/09205063.2012.757727

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of capillary-like network in a matrix of water-soluble polymer using poly(methyl methacrylate) microfibers2012

    • Author(s)
      Takayuki Takei, Naoya Kishihara, Hiroyuki Ijima and Koei Kawakami
    • Journal Title

      Artificial Cells, Blood Substitutes, and Biotechnology

      Volume: 40 Issue: 1-2 Pages: 66-69

    • DOI

      10.3109/10731199.2011.592492

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
  • [Presentation] Injectable and biodegradable sugar beet pectin-based hydrogels for biomedical applications2012

    • Author(s)
      Takayuki Takei, Kotaro Sugihara, Hiroyuki Ijima and Koei Kawakami
    • Organizer
      The 10th Japan-Korea Symposium on Materials & Interface - International Symposium on Frountiers in Chemical Engineering -
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Injectable and biodegradable sugar beet pectin-based hydrogels for biomedical applications2012

    • Author(s)
      Takayuki Takei
    • Organizer
      The 10th Japan-Korea Symposium on Materials & Interface -International Symposium on Frontiers in Chemical Engineering-
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://kuris.cc.kagoshima-u.ac.jp/714489.html

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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