| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Here, we attempted to generate genetically manipulated chickens producing human T -cell epitopes derived from Japanese cedar pollen and anti-allergic cytokine, TGF-ss in order to develop a treatment fro pollen allergy by inducing oral tolerance. The number of sneezing and the allergen-specific IgE level were significantly decreased in allergic mice fed with T-cell epitope-containing egg white. GM chickens harboring TGF-ssgene were generated using oviduct-specific expression system. GM chicken model will extend the usage of therapeutic proteins in eggs, which may serve as edible pharmaceuticals for allergy immunotherapy based on oral tolerance.
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