Identification of marine biocompound producers within sponges using the single-cell approach and their in vitro cultivation
| Project/Area Number |
23760755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Waseda University |
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Principal Investigator |
MORI Tetsushi 早稲田大学, 理工学術院, 助教 (00590100)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 微生物 / 海洋資源 / 生態学 / 単一細胞解析 |
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| Research Abstract |
Marine sponges are considered as the largest producers of highly significant natural compounds. In this research, the goal was to apply the single cell analytical approach to identify the real producers of such important compounds. Targeting the compound Onnamide A, the research was successful in identifying the true producer and reported the first identification of a natural compound producer from uncultivated bacteria. Further genomic analysis also revealed that this bacterium harbored numerous biosynthetic pathways, similar to that of its cultivable counterparts such as Pseudomonas, Bacillus and actinomycetes.
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Report
(3 results)
Research Products
(11 results)
