| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Amyloid beta which is causative agent of Alzheimer's disease is widely known to form aggregate nucleation by binding with ganglioside GM1, and this nucleation is suggested to enhance aggregation of amyloid beta in vivo. In this study, the synthesis of non-native form ganglioside based on GM1 structure was investigated to clarify the interaction between ganglioside and amyloid beta. We examined synthesis pathway of GM1-type glycan which possess reactive site by click chemistry, and obtained optimal synthesis method.
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