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Investigations on Radiobiological effects induced by high dose rate irradiation with laser-accelerated protons.

Research Project

Project/Area Number 23760831
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nuclear engineering
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

YOGO Akifumi  独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 (50421441)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords放射線工学 / ビーム科学 / レーザー駆動粒子線 / レーザーイオン加速 / 高強度レーザー / 放射線生物効果 / 高線量率照射 / レーザー物質相互作用 / レーザー粒子加速
Research Abstract

Recently, high-intensity laser ion acceleration has been suggested as a potential, cost-saving alternative technology to conventional accelerators for radiotherapy. In this work, investigations of the biological effects of the high bunch current and short bunch duration, that are typical of laser-acceleration, are reported. The radiobiological effects of high dose-rate irradiation with laser-driven proton beams are compared with those of beams derived from conventional ion accelerators.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] レーザー駆動陽子線の生物照射効果(勧誘論文)2012

    • Author(s)
      余語覚文
    • Journal Title

      レーザー学会誌「レーザー研究」

      Volume: 40 Pages: 842-842

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] レーザー駆動陽子線の生物実験への応用2012

    • Author(s)
      余語覚文
    • Journal Title

      J. Plasma Fusion Res.

      Volume: 88 Pages: 21-24

    • NAID

      110009328149

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] レーザー駆動陽子線の生物照射効果2012

    • Author(s)
      余語 覚文
    • Journal Title

      レーザー学会誌「レーザー研究」

      Volume: 40 Pages: 842-849

    • NAID

      10031127749

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レーザー駆動陽子線の生物実験への応用2012

    • Author(s)
      余語 覚文
    • Journal Title

      Journal of Plasma and Fusion Ressearch

      Volume: 1 Pages: 25-31

    • NAID

      110009328149

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Measurement of DNA Double-Strand Break Yield in Human Cancer Cells by High Current, Short Duration Bunches of Laser-Accelerated Protons2011

    • Author(s)
      Akifumi Yogo, Katsutoshi Sato, Masaharu Nishikino, Takuya Maeda, Hironao Sakaki, Toshihiko Hori, Koichi Ogura, Mamiko Nishiuchi, Teruki Teshima, Hiroaki Nishimura, Kiminori Kondo, Paul R. Bolton, and Shunichi Kawanishi
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 50 Pages: 106401-106401

    • NAID

      210000139770

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of DNA Double-Strand Break Yield in Human Cancer Cells by High-Current, Short-Duration Bunches of Laser-Accelerated Protons2011

    • Author(s)
      A. Yogo, K. Sato, M. Nishikino et al.
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 50 Issue: 10R Pages: 106401-106401

    • DOI

      10.1143/jjap.50.106401

    • NAID

      210000139770

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] レーザー駆動イオン加速のための10TW級高コントラストレーザーの開発2013

    • Author(s)
      余語覚文, 他
    • Organizer
      レーザー学会学術講演会 第33回年次大会
    • Place of Presentation
      姫路市
    • Related Report
      2012 Final Research Report
  • [Presentation] レーザー駆動イオン加速のための10TW級高コントラストレーザーの開発2013

    • Author(s)
      余語 覚文
    • Organizer
      レーザー学会学術講演会第33 回年次大会
    • Place of Presentation
      姫路商工会議所 姫路市
    • Related Report
      2012 Annual Research Report
  • [Presentation] レーザー駆動イオン加速とその生物応用研究2012

    • Author(s)
      余語覚文, 他
    • Organizer
      日本物理学会第67回年次大会 若手奨励賞受賞講演
    • Place of Presentation
      関西学院大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Radiobiology with Laser-accelerated Proton Beams2012

    • Author(s)
      A. Yogo, et al.
    • Organizer
      ICACS International Conference on "Atomic Collisions in Solids "-25
    • Place of Presentation
      Kyoto, JAPAN
    • Related Report
      2012 Final Research Report
  • [Presentation] 精密に時間制御された高強度レーザーによるイオン加速2012

    • Author(s)
      余語覚文
    • Organizer
      レーザー学会学術講演会第32回年次大会、レーザー学会業績賞受賞記念講演
    • Place of Presentation
      TKP 仙台カンファレンスセンタ
    • Related Report
      2012 Final Research Report
  • [Presentation] Radiobiology with Laser-accelerated Proton Beams2012

    • Author(s)
      Akifumi Yogo
    • Organizer
      ICACS-25, International Conference on Atomic Collisions in Solids
    • Place of Presentation
      Kyoto University, Kyoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] レーザー駆動イオン加速とその生物応用研究2012

    • Author(s)
      余語覚文
    • Organizer
      日本物理学会第67回年次大会(招待講演)
    • Place of Presentation
      関西学院大学
    • Related Report
      2011 Research-status Report
  • [Presentation] レーザー駆動陽子線によるヒトがん細胞生存率RBE 測定2011

    • Author(s)
      余語覚文, 他
    • Organizer
      日本原子力学会 2011 年秋の大会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Radiobiology with laser-accelerated ion beams: Application of the quasi -monoenergetic proton2011

    • Author(s)
      A. Yogo, et al.
    • Organizer
      The 3rd International Symposium on Laser-driven relativistic plasmas applied for science, industry and medicine
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Radiobiology with laser accelerated quasi -monoenergetic proton beams2011

    • Author(s)
      A. Yogo, et al.
    • Organizer
      SPIE Optics + Optoelectronics 2011
    • Place of Presentation
      Czech Republic
    • Related Report
      2012 Final Research Report
  • [Presentation] Radiobiology with laser-accelerated quasi-monoenergetic proton beams2011

    • Author(s)
      A. Yogo
    • Organizer
      SPIE Optics + Optoelectronics 2011(招待講演)
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2011 Research-status Report
  • [Presentation] レーザー駆動陽子線によるヒトがん細胞生存率RBE測定2011

    • Author(s)
      余語覚文
    • Organizer
      日本原子力学会 2011年秋の大会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] レーザー装置用ビームライン、レーザー装置2013

    • Inventor(s)
      余語覚文、近藤公伯
    • Industrial Property Rights Holder
      独立行政法人日本原子力研究開発機構
    • Filing Date
      2013-01-16
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] レーザー装置用ビームライン、レーザー装置2013

    • Inventor(s)
      余語覚文、近藤公伯
    • Industrial Property Rights Holder
      独立行政法人日本原子力研究開発機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-01-06
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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