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The role of host factors in LINE retrotransposition

Research Project

Project/Area Number 23770004
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Genetics/Genome dynamics
Research InstitutionTokyo Institute of Technology

Principal Investigator

KAJIKAWA Masaki  東京工業大学, 大学院・生命理工学研究科, 講師 (90361766)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsゲノム構築 / 再編 / 維持 / 転移因子 / レトロトランスポゾン
Research Abstract

Transposable elements, including LINEs, are major components of eukaryotic genomes. They mobilize and amplify their own copies via the reverse transcription of their own RNA. This mobilization mechanism is called retrotransposition, and it requires proteins encoded by transposable elements. However, retrotransposition is not completed by the proteins only, and host encoded proteins are most likely required for retrotransposition. This study found that a retrotransposition intermediate of LINEs contains a large amount of host encoded proteins, which probably participate in retrotransposition.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] A new mechanism to ensure integration during LINE retrotransposition: a suggestion from analyses of the 5' extra nucleotides.2012

    • Author(s)
      Kajikawa M, Yamaguchi K, Okada N.
    • Journal Title

      Gene

      Volume: 505 Issue: 2 Pages: 345-351

    • DOI

      10.1016/j.gene.2012.02.047

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low dependency of retrotransposition on the ORF1 protein of the zebrafish LINE, ZfL2-1.2012

    • Author(s)
      Kajikawa M, Sugano T, Sakurai R, Okada N.
    • Journal Title

      Gene

      Volume: 499 Issue: 1 Pages: 41-47

    • DOI

      10.1016/j.gene.2012.02.048

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-interaction, nucleic acidbinding,and nucleic acid chaperone activities are unexpectedly retained in the unique ORF1p of zebrafish LINE.2011

    • Author(s)
      Nakamura M, Okada N, Kajikawa M.
    • Journal Title

      Mol.Cell.Biol.

      Volume: 32 Issue: 2 Pages: 458-469

    • DOI

      10.1128/mcb.06162-11

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-interaction, nucleic acid binding, and nucleic acid chaperone activities are unexpectedly retained in the unique ORF1p of zebrafish LINE.2011

    • Author(s)
      Nakamura M, Okada N, Kajikawa M.
    • Journal Title

      Mol Cell Biol

      Volume: 32 Pages: 458-469

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] The zebrafish LINE, ZfL2-1, has a potential to obtain a novel coding sequence in its ORF1p coding region2011

    • Author(s)
      Masaki Kajikawa.
    • Organizer
      Mobile DNA in Mammalian Genomes
    • Place of Presentation
      Snowmass Village,Colorado,USA.
    • Year and Date
      2011-08-10
    • Related Report
      2012 Final Research Report
  • [Presentation] The zebrafish LINE, ZfL2-1, has a potential to obtain a novel coding sequence in its ORF1p coding region.2011

    • Author(s)
      Masaki Kajikawa
    • Organizer
      Mobile DNA in Mammalian Genomes
    • Place of Presentation
      Snowmass Village, Colorado, USA
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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