Starvation dependent epigenetic change and its inheritance

• Project/Area Number: 23770010
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Genetics/Genome dynamics
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SEONH Ki-hyeon 独立行政法人理化学研究所, 石井分子遺伝学研究室, 客員研究員 (40425632)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: epigenetics / drosophila melanogaster / dATF-2 / stress / ショウジョウバエ / ATF-2 / ストレス / エピジェネティクス / エピジェネティック

Research Abstract

I revealed that nutrition stress affects heterochromatin formation. Gene expression array analysis showed that dATF-2 might play a central role in inheritance of stress dependent epigenome change.

Research Products

• [Journal Article] Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk (2013)
  • Author(s): Seong KH, Ishii S.
  • Journal Title: Genes to Cells Volume: 18(1) Pages: 66-78
  • Peer Reviewed
• [Journal Article] Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors (2012)
  • Author(s): Seong KH, Maekawa T, Ishii S.
  • Journal Title: Genes to Cells Volume: 17(4) Pages: 249-163
  • Peer Reviewed
• [Journal Article] 環境・栄養ストレスによるエピジェネティック変化の遺伝と疾患 (2012)
  • Author(s): 成耆鉉
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 35(2) Pages: 135-140
  • NAID: 40019419089
• [Journal Article] Inheritance and memory of stress-induced epigenome change : roles played by the ATF-2 family of transcription factors (2012)
  • Author(s): Seong KH, Maekawa T & Ishii S
  • Journal Title: Genes Cells Volume: 17 Issue: 4 Pages: 249-263
  • DOI: 10.1111/j.1365-2443.2012.01587.x
  • Peer Reviewed
• [Journal Article] Inheritance of Stress-induced, ATF-2-Dependent Epigenetic Change. (2011)
  • Author(s): Seong KH, Li D, Shimizu H, Nakamura R & Ishii S.
  • Journal Title: Cell Volume: 145(7) Pages: 1049-1061
  • Peer Reviewed
• [Journal Article] Inheritance of stress-induced, ATF-2-dependent epigenetic change (2011)
  • Author(s): Seong KH, Li D, Shimizu H, Nakamura R, Ishii S
  • Journal Title: Cell Volume: 145 Issue: 7 Pages: 1049-1061
  • DOI: 10.1016/j.cell.2011.05.029
  • Peer Reviewed
• [Presentation] ショウジョウバエにおけるストレス依存的エピジェネティック制御とその遺伝の解析 (2012)
  • Author(s): 成 耆鉉、李 棟,中邑 亮一,石井 俊輔
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] ショウジョウバエにおけるストレス依存的エピジェネティック制御とその遺伝の解析 (2012)
  • Author(s): 成 耆鉉
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Book] Chapter 6 Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors Stress-Induced Mutagenesis, David Mittelman(Ed) (2013)
  • Author(s): Seong KH, Maekawa T, Ishii S.
  • Publisher: Springer-Verlag New York Inc.
• [Book] Stress-Induced Mutagenesis (2013)
  • Author(s): David Mittelman(Ed)
  • Publisher: Springer-Verlag New York Inc.
• [Book] 「環境・栄養ストレスによるエピジェネティック変化の遺伝と疾患」内分泌・糖尿病・代謝内科 (2012)
  • Author(s): 成耆鉉、前川利男、石井俊輔
• [Book] ストレスによるエピゲノム変化とその遺伝 実験医学 (2011)
  • Author(s): 成耆鉉、石井俊輔