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Molecular mechanism of a phenotypic adaptation to establishment of a synthetic bacterial mutualism

Research Project

Project/Area Number 23770021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ecology/Environment
Research InstitutionOsaka University

Principal Investigator

HOSODA Kazufumi  大阪大学, 大学院・情報科学研究科, 招へい准教授 (30515565)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords個体群 / 実験室内共生系 / 共生成立 / 表現型可塑性 / 分子機構 / 共生の進化 / 協力の進化 / 人工生態系 / 人工共生系 / 実験室内進化
Research Abstract

Mutualism is ubiquitous in nature, and its establishment and evolution are important issues in ecology. To understand how organisms adapt to the first encounter with another organism to establish and evolve mutualism, experimental reconstruction of these processes is a useful strategy. Previously, we experimentally simulated the establishment of mutualism using two genetically-engineered auxotrophic strains of Escherichia coli, and found that one strain rapidly changed its phenotype, eventually leading to the establishment of the mutualism. Here we show not only the molecular basis of the observed phenotypic change, but also the experimental evolution of this mutualism.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (19 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Construction of bacteria-eukaryote synthetic mutualism.2013

    • Author(s)
      I. Kubo, K. Hosoda, S. Suzuki, K. Yamamoto, K. Kihara, K. Mori, T. Yomo
    • Journal Title

      BioSystems

      Volume: (accepted) Issue: 2 Pages: 66-71

    • DOI

      10.1016/j.biosystems.2013.05.006

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrodynamic trapping of Tetrahymena thermophila for the long-term monitoring of cell behaviors.2012

    • Author(s)
      I. Kumano, K. Hosoda, H. Suzuki, K. Hirata, T. Yomo
    • Journal Title

      Lab on a chip

      Volume: 12 Issue: 18 Pages: 3451-3451

    • DOI

      10.1039/c2lc40367f

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Experimental evolution of an artificial bacterial mutualism.2012

    • Author(s)
      K. Hosoda, A. Asao, S. Suzuki, T. Yomo
    • Journal Title

      Proceedings of Artificial Life 13 (MIT press)

      Volume: 523

    • URL

      http://mitpress.mit.edu/books/artificial-life-13

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Experimental evolution of an artificial bacterial mutualism.2012

    • Author(s)
      Kazufumi Hosoda, Akihiro Asao, Shingo Suzuki, Tetsuya Yomo.
    • Journal Title

      Proceedings of Artificial Life 13

      Volume: 13 Pages: 523-524

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Designing symbiosis.2011

    • Author(s)
      K.Hosoda, T.Yomo
    • Journal Title

      Bioengineered bugs

      Volume: 2 Issue: 6 Pages: 338-338

    • DOI

      10.4161/bbug.2.6.16801

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Experimental evolution of an artificial bacterial mutualism2012

    • Author(s)
      K. Hosoda
    • Organizer
      複雑系生命システム研究センターセミナー
    • Place of Presentation
      東京大学
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 協力の進化について実験進化が出してきた一つの解2012

    • Author(s)
      細田一史, 浅尾晃央, 鈴木真吾, 四方哲也
    • Organizer
      第28回個体群生態学会大会
    • Place of Presentation
      東邦大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Experimental evolution of synthetic microbial symbioses.2012

    • Author(s)
      K. Hosoda, M. Sueyoshi, A. Asao, I. Kumano, S. Suzuki, T. Yomo.
    • Organizer
      Joint meeting of the 28th Annual Meeting of the Japanese Society of Microbial Ecology (JSME2012), and the 4th Japan-Korea International Symposium on Microbial Ecology (JK-ISME 2012).
    • Place of Presentation
      Toyohashi University, Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] Experimental evolution of an artificial bacterial mutualism.2012

    • Author(s)
      K. Hosoda, A. Asao, S. Suzuki, T. Yomo.
    • Organizer
      The Thirteenth International Conference on the Synthesis and Simulation of Living Systems (Artificial Life XIII)
    • Place of Presentation
      Michigan State University, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Synthesizing symbiosis2012

    • Author(s)
      K. Hosoda, A. Asao, S. Suzuki, T. Yomo.
    • Organizer
      Joint Meeting of The 59th Annual Meeting of the Ecological Society of Japan and the 5th EAFES International Congress
    • Place of Presentation
      Ryukoku University, Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] なぜ生物は共生するのか?実験的に再構成して考える2012

    • Author(s)
      細田一史
    • Organizer
      第23回 計測自動制御学会 SI 部門共創システム部会研究会・第6回 内部観測研究会
    • Place of Presentation
      神戸大学.
    • Related Report
      2012 Final Research Report
  • [Presentation] Experimental evolution of synthetic microbial symbioses.2012

    • Author(s)
      Kazufumi Hosoda, Makoto Sueyoshi, Akihiro Asao, Itsuka Kumano, Shingo Suzuki, Tetsuya Yomo.
    • Organizer
      "第28回日本微生物生態学会大会(JSME 2012)/ 第4回日韓微生物生態シンポジウム(JK-ISME2012)"
    • Place of Presentation
      豊橋技術科学大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Experimental evolution of an artificial bacterial mutualism.2012

    • Author(s)
      Kazufumi Hosoda, Akihiro Asao, Shingo Suzuki, Tetsuya Yomo.
    • Organizer
      The Thirteenth International Conference on the Synthesis and Simulation of Living Systems (Artificial Life XIII)
    • Place of Presentation
      "Michigan State University in East Lansing, Michigan, USA "
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesizing symbiosis.2012

    • Author(s)
      Kazufumi Hosoda, Akihiro Asao, Shingo Suzuki, Tetsuya Yomo.
    • Organizer
      Joint Meeting of The 59th Annual Meeting of the Ecological Society of Japan and the 5th EAFES International Congress
    • Place of Presentation
      Seta Campus, Ryukoku University, Japan
    • Related Report
      2012 Annual Research Report 2011 Research-status Report
  • [Presentation] 創ってわかった協力の進化2012

    • Author(s)
      細田一史, 末吉眞人, 浅尾晃央, 熊野いつか, 鈴木真吾, 四方哲也
    • Organizer
      「細胞を創る」研究会5.0
    • Place of Presentation
      東京工業大学すずかけ台キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] 協力の進化について実験進化が出してきた一つの解2012

    • Author(s)
      細田一史, 浅尾晃央, 鈴木真吾, 四方哲也
    • Organizer
      第28回個体群生態学会大会
    • Place of Presentation
      東邦大学理学部(東邦大学・習志野キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Experimental evolution of a synthetic symbiosis./人工共生系の実験進化2012

    • Author(s)
      細田一史, 浅尾晃央, 鈴木真吾, 四方哲也
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学 東山キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] 人工共生の実験進化2012

    • Author(s)
      細田一史,末吉眞人,浅尾晃央,熊野いつか,鈴木真吾,四方哲也
    • Organizer
      日本進化学会第14回東京大会
    • Place of Presentation
      首都大学東京南大沢キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Experimental evolution of an artificial bacterial mutualism2012

    • Author(s)
      Kazufumi Hosoda
    • Organizer
      複雑系生命システム研究センターセミナー(招待講演)
    • Place of Presentation
      東京大学
    • Related Report
      2011 Research-status Report
  • [Presentation] なぜ生物は共生するのか?実験的に再構成して考える2012

    • Author(s)
      細田一史
    • Organizer
      第23回 計測自動制御学会SI部門共創システム部会研究会・第6回 内部観測研究会(招待講演)
    • Place of Presentation
      神戸大学六甲台キャンパス 百年記念館 六甲ホール
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthesizing symbiosis.2011

    • Author(s)
      K. Hosoda, A. Asao, S. Suzuki, T. Yomo
    • Organizer
      International Symposium on Synthesizing life and biological Systems
    • Place of Presentation
      Life Science Center, Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] 細菌によるモデル相利共生(協力系)は空間構造等が無くても進化した2011

    • Author(s)
      細田一史、浅尾晃央、鈴木真吾、四方哲也
    • Organizer
      第27回個体群生態学会大会
    • Place of Presentation
      岡山大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Synthesizing symbiosis.2011

    • Author(s)
      Kazufumi Hosoda, Akihiro Asao, Shingo Suzuki, Tetsuya Yomo
    • Organizer
      International Symposium on Synthesizing life and biological systems
    • Place of Presentation
      Life Science Center,Osaka,Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] 細菌によるモデル相利共生(協力系)は空間構造等が無くても進化した2011

    • Author(s)
      細田一史、浅尾晃央、鈴木真吾、四方哲也
    • Organizer
      第27回個体群生態学会大会
    • Place of Presentation
      岡山大学創立五十周年記念館・岡山大学農学部1号館
    • Related Report
      2011 Research-status Report
  • [Remarks] (1) 国際会議受賞:K. Hosoda, Evolution in action Best Poster (2012)

    • Related Report
      2012 Final Research Report
  • [Remarks] (2) Web ページ

    • URL

      http://www.dma.jim.osaka-u.ac.jp/view?l=ja&u=2939

    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学 細田一史 研究タブに業績一覧記載

    • URL

      http://www.dma.jim.osaka-u.ac.jp/view?l=ja&u=2939

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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