Study of calcitonin (CT) family in an amphioxus, Branchiostoma floridae : Coevolution among CT peptide, CT receptor, and receptor activity- modifying protein.
Project/Area Number |
23770069
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
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Research Institution | Kanazawa University (2012) Suntory Foundation for Life Sciences (2011) |
Principal Investigator |
SEKIGUCHI Toshio 金沢大学, 環日本海域環境研究センター, 助教 (40378568)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | Calcitonin / Calcitonin receptor / RAMP / ナメクジウオ / Calcitonin 受容体 / 受容体修飾蛋白 / 分子進化 / 比較内分泌学 |
Research Abstract |
Calcitonin (CT) family shows high molecular and functional diversification in vertebrates. To elucidate the origin of CT family, CT peptide, CT receptor (CTR), and receptor activity-modifying protein (RAMP) were identified from an amphioxus, Branchiostoma floridae, which is close animal of vertebrates. Furthermore, analysis ofCTR and RAMP expressed in mammalian cell line demonstrated that co-expression of CTR and RAMP is required for ligand activity of CT peptide, and that RAMP is necessary for cell-surface translocation of CTR. These results let us conclusion that CT peptide, CTR, and RAMP have already existed in the common ancestor between vertebrates and amphioxus.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Determination of calcium sensing receptor in the scales of goldfish and induction of its mRNA expression by acceleration loading.2012
Author(s)
Kakikawa, M., Yamamoto, T., Chowdhury, V.S., Satoh, Y., Kitamura, K., Sekiguchi, T., et. al.
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Journal Title
Biol. Sci. Space
Volume: 26
Pages: 26-31
NAID
Related Report
Peer Reviewed
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