Study on regulatory mechanisms of the expression and secretion of insulin-like peptides
Project/Area Number |
23770071
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
OKAMOTO Naoki 独立行政法人理化学研究所, 成長シグナル研究チーム, 基礎科学特別研究員 (10577969)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | インスリン様ペプチド / インスリン産生細胞 / 成長 / ショウジョウバエ / インスリン / インスリン様成長因子(IGF) / 栄養 / 比較内分泌 / 生理・内分泌学 / 比較内分泌学 / 昆虫 |
Research Abstract |
Regulatory mechanisms of the function of insulin-like peptides (ILPs) were analyzed by using fruit fly Drosophila melanogaster and mammalian pancreatic β cells-derived cell line. We found that the evolutionally conserved regulatory mechanism of the insulin expression by two transcriptional factors, Dachshund and Eyeless. We further characterized a novel ILPs-binding protein called secreted decoy of InR (SDR) that binds to ILPs in the circulating hemolymph and antagonizes insulin/IGF signaling during development.
|
Report
(3 results)
Research Products
(47 results)