Analysis of the molecular properties of vertebrate novel UV-absorbing proteins
| Project/Area Number |
23770074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 動物生理化学 / 光受容 / 蛋白質 / 紫外光 / 脳・神経 |
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| Research Abstract |
We analyzed the molecular properties of Opn5 group which contains photoreceptive proteins widely distributed in vertebrates. We revealed that, among several subgroups of Opn5 group, Opn5m and Opn5L2 can bind 11-cis-retinal to form UV-sensitive pigments and photoisomerization into all-trans-retinal results in G protein activation. In addition, non-mammalian Opn5m and Opn5L2 can also directly bind all-trans-retinal to activate G protein without light irradiation. These data suggest that Opn5 proteins possibly provide the molecular basis for UV reception in vertebrates including humans and non-mammalian Opn5 proteins are also responsible for non-photoreceptive function.
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Report
(3 results)
Research Products
(49 results)
