Molecular recognition of HLA-G6 isoform with LILR family
| Project/Area Number |
23770102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural biochemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUROKI Kimiko 北海道大学, 大学院・薬学研究院, 助教 (90553313)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | HLA-G6 / 構造解析 / 相互作用解析 / LILR / X線結晶構造解析 / 電子顕微鏡 / NMR / ホモ二量体 |
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| Research Abstract |
I performed the analysis at the protein level about the interaction with HLA-G6 isoform and the LILR receptor. At first I established the expression system of stable HLA-G6 protein by E.coli. In addition, I performed structural analyses of HLA-G6 and the complex with its receptor, LILRB2, by several techniques (X-ray crystallography, cryo-EM, NMR).
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Report
(3 results)
Research Products
(9 results)
