Relation between the function of lipids and diseases using mass spectrometry imaging

• Project/Area Number: 23770116
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural biochemistry
• Research Institution: 独立行政法人国立がん研究センター (2012); Osaka University (2011)
• Principal Investigator: SHIMMA Shuichi 独立行政法人国立がん研究センター, 研究所, 研究員 (30515896)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: イメージング質量分析 / タンデム質量分析 / 複合脂質 / 高エネルギー衝突誘起解離 / 脂質 / イメージングマス

Research Abstract

In this study, the structural analysis of sulfatide directly on the mouse brain section was performed using mass spectrometry imaging. As a result, the novel ceramide structure contained in the sulfatide was revealed.

Research Products

• [Journal Article] 質量分析イメージングで抗がん剤を見る-新規Pharmaco-imaging法とその応用- (2013)
  • Author(s): 新間秀一、濱田哲暢
  • Journal Title: 薬剤学 Volume: 73 Pages: 34-39
  • NAID: 10031171082
• [Journal Article] 質量分析イメージングで抗がん剤を見る ―新規 Pharmaco-imaging 法とその応用― (2013)
  • Author(s): 新間秀一
  • Journal Title: 薬剤学 Volume: 73 Pages: 34-39
  • NAID: 10031171082
  • Peer Reviewed
• [Journal Article] Detailed structural analysis of lipids directly on tissue specimens using a MALDI-SpiralTOF-Reflectron TOF mass spectrometer (2012)
  • Author(s): Shuichi Shimma, Ayumi Kubo, Takaya Satoh, Michisato Toyoda
  • Journal Title: PLoS One Volume: 7
• [Journal Article] Mass Spectrometry imaging and structural analysis of lipids directly on tissue specimens by using a spiral orbit type tandem time-of-flight mass spectrometer, SpiralTOF-TOF (2012)
  • Author(s): Takaya Satoh, Ayumi Kubo, Shuichi Shimma, Michisato Toyoda
  • Journal Title: Mass Spectrometry Volume: 1
  • NAID: 10031126350
• [Journal Article] Detailed structural analysis of lipids directly on tissue specimens using a MALDI-SpiralTOF-Reflectron TOF mass spectrometer. (2012)
  • Author(s): Shuichi Shimma
  • Journal Title: PLoS ONE Volume: 7 Issue: 5 Pages: e37107-e37107
  • DOI: 10.1371/journal.pone.0037107
  • Peer Reviewed
• [Book] 実験医学別冊 (2013)
  • Author(s): 新間秀一
  • Total Pages: 9
  • Publisher: 羊土社