Studies on the physiological functions of the extrace I lular phosphory lat ion of atypical cadherins
| Project/Area Number |
23770139
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 翻訳後修飾 / カドヘリン / ゴルジ体キナーゼ / ショウジョウバエ / リン酸化 |
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| Research Abstract |
Fat is an atypical cadherin that regulates growth and planer cell polarity in Drosophila development. In this study, we focused on the physiological roles of extracellular phosphorylation of Fat cadherin domains, by using transgenic flies. We found that phosphorylation of the third cadherin domain of Fat is required for normal development in Drosophila.
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Report
(3 results)
Research Products
(20 results)
