Structural study on the generation mechanism of nitrous oxide by integral membrane protein nitric oxide reductase
| Project/Area Number |
23770144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tottori University |
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Principal Investigator |
HINO Tomoya 鳥取大学, 大学院・工学研究科, 講師 (40373360)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 金属タンパク質 / 膜蛋白質 / 一酸化窒素還元酵素 / 亜酸化窒素 / 呼吸酵素 / 抗体 / 膜タンパク質 / X線結晶構造解析 / 分子進化 |
|---|
| Research Abstract |
Bacterial nitric oxide reductase is a membrane integral enzyme that catalyzes the reduction of nitric oxide to nitrous oxide during the nitrate respiration, an anaerobic respiration of facultative anaerobic organisms. In the present study, I determined the crystal structure of nitric oxide reductase from Pseudomonas aeruginosa in the fully reduced state and revealed that no obvious structural changes were induced including active site upon reduction of all metal sites
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] G-protein coupled receptor inactivation by an allosteric inverse-agonist antibody2012
Author(s)
Hino T., Arakawa H., Iwanari H., Yurugi-Kobayashi T., Ikeda-Suno C., Nakada-Nakura Y., Kusano-Arai O., Weyand S., Shimamura T., Nomura N., Cameron A. D., Kobayashi T., Hamakubo T., Iwata S., Murata T.
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Journal Title
Nature
Volume: 482
Pages: 237-240
Related Report
Peer Reviewed
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[Journal Article]2012
Author(s)
Shiro Y., Sugimoto H., Tosha T., Nagano S., Hino T.
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Journal Title
Philos. Trans. Soc. Lond. B Biol. Sci.
Volume: 367
Pages: 1195-1203
Related Report
Peer Reviewed
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