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Measurement of cellular dynamics using digital image correlation method

Research Project

Project/Area Number 23770167
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biophysics
Research InstitutionHokkaido University

Principal Investigator

MIZUTANI Takeomi  北海道大学, 先端生命科学研究科(研究院), 助教 (40451405)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオイメージング / 生物物理学 / バイオメカニクス / 力学測定 / ライブセルイメージング / 画像解析
Research Abstract

Using live cell imaging and digital image correlation method, we measured cytoskeletal dynamics. This method will be helpful to study mechanical interaction between cytoskeletons or cellular contractile force in 3D.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (14 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] Modulation of extracellular conditions prevents the multilayering of the simple epithelium2014

    • Author(s)
      T. Mizutani, K. Takeda, H. Haga, M. Todo, K. Kawabata
    • Journal Title

      Histochemistry and Cell Biology

      Volume: Vol. 141(5) Issue: 5 Pages: 459-471

    • DOI

      10.1007/s00418-013-1176-8

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tempo-Spatial Change of Cellular Stiffness and Geometry in the Process of Developing Epithelial Cell-Cell Adhesion Measured by Atomic Force Microscopy2013

    • Author(s)
      R. Tanaka, T. Mizutani, H. Haga, K. Kawabata
    • Journal Title

      Japanese Journal of Applied Physics Conference Proceedings

      Volume: Vol. 1

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain2013

    • Author(s)
      Ishihara S, Yasuda M, Nishioka T, Mizutani T, Kawabata K, Shirato H, Haga H
    • Journal Title

      FEBS Lett

      Volume: 587(6) Issue: 6 Pages: 732-736

    • DOI

      10.1016/j.febslet.2013.01.055

    • NAID

      120005228631

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions2013

    • Author(s)
      Seiichiro Ishihara, Motoaki Yasuda, Ichiro Harada, Takeomi Mizutani, Kazushige Kawabata, Hisashi Haga
    • Journal Title

      Experimental Cell Research

      Volume: 319(19) Issue: 19 Pages: 2916-2927

    • DOI

      10.1016/j.yexcr.2013.09.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasiveness2013

    • Author(s)
      Xue Li, Seiichiro Ishihara, Motoaki Yasuda, Takeshi Nishioka, Takeomi Mizutani, Masayori Ishikawa, Kazushige Kawabata, Hiroki Shirato, Hisashi Haga
    • Journal Title

      PLoS One

      Volume: 8(8) Issue: 8 Pages: 1-12

    • DOI

      10.1371/journal.pone.0070905

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal correlates of multiple top-down signals during covert tracking of moving objects in macaque prefrontal cortex2012

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      J. Cogn. Neurosci

      Volume: 24 Issue: 01 Pages: 2043-2056

    • DOI

      10.4236/cellbio.2012.11001

    • NAID

      120005090600

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice2012

    • Author(s)
      N.Seito, et al.
    • Journal Title

      Arthritis & Rheumatism

      Volume: (印刷中) Issue: 8 Pages: 2579-88

    • DOI

      10.1002/art.34463

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷武臣
    • Journal Title

      M&M2012材料力学カンファレンス論文集

    • Related Report
      2013 Final Research Report
  • [Journal Article] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷 武臣
    • Journal Title

      M&M2012材料力学カンファレンス論文集

      Volume: M&M2012

    • Related Report
      2012 Research-status Report
  • [Journal Article] Active fluctuation in the cortical cytoskeleton observed by high-speed live-cell scanning probe microscopy2011

    • Author(s)
      K.Tamura, T.Mizutani, H.Haga, K.Kawabata
    • Journal Title

      Acta Biomater.

      Volume: 7 Issue: 10 Pages: 3766-3772

    • DOI

      10.1016/j.actbio.2011.06.013

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 細胞の力学コミュニケーション2013

    • Author(s)
      水谷武臣
    • Organizer
      大阪府立母子保健総合医療センター研究所セミナー
    • Place of Presentation
      大阪府立母子保健総合医療センター研究所(和泉市)
    • Year and Date
      2013-11-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞の力学コミュニケーション2013

    • Author(s)
      水谷 武臣
    • Organizer
      研究所セミナー
    • Place of Presentation
      大阪府立母子保健総合医療センター研究所(和泉市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tempo-spatial Change of Cellular Stiffness in the Process of Developing Epithelial Cell-cell Adhesion Measured by Atomic Force Microscopy2012

    • Author(s)
      R. Tanaka, T. Mizutani, H. Haga, K. Kawabata
    • Organizer
      20th International Colloquium on Scanning Probe Microscopy
    • Place of Presentation
      Okinawa Kariyushi Urban Resort Naha(那覇市)
    • Year and Date
      2012-12-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷武臣
    • Organizer
      M&M2012材料力学カンファレンス
    • Place of Presentation
      愛媛大学(松山市)
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of microtubule deformation by live cell imaging and image analysis2012

    • Author(s)
      R. Tanaka, T. Mizutani, H. Haga, K. Kawabata
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 画像解析を用いた細胞内外の力学量計測2012

    • Author(s)
      水谷武臣
    • Organizer
      第四回「光塾」
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-08-26
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 細胞骨格に発生した不均一な歪み : ライブセルイメージングと画像解析による力学量測定法の提案2012

    • Author(s)
      田中良昌、水谷武臣、芳賀永、川端和重
    • Organizer
      2011年度日本生物物理学会北海道支部例会
    • Place of Presentation
      旭川市民文化会館(旭川市)
    • Year and Date
      2012-03-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Tempo-spatial Change of Cellular Stiffness in the Process of Developing Epithelial Cell-cell Adhesion Measured by Atomic Force Microscopy2012

    • Author(s)
      Ryosuke Tanaka, Takeomi Mizutani, Hisashi Haga, Kazushige Kawabata
    • Organizer
      20th International Colloquium on Scanning Probe Microscopy
    • Place of Presentation
      Okinawa Kariyushi Urban Resort Naha(沖縄県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷 武臣
    • Organizer
      M&M2012 材料力学カンファレンス
    • Place of Presentation
      愛媛大学(松山市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 細胞骨格に発生した不均一な歪み:ライブセルイメージングと画像解析による力学量測定法の提案2012

    • Author(s)
      田中良昌、水谷武臣、芳賀永、川端和重
    • Organizer
      2011 年度日本生物物理学会北海道支部例会
    • Place of Presentation
      旭川市民文化会館(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Imaging for Cellular Mechanics : Dynamic Behavior of Cytoskeletal Networks and Cellular Contractile Force2011

    • Author(s)
      T. Mizutani
    • Organizer
      The Fifth Shanghai International Conference on Biophysics and Molecular Biology
    • Place of Presentation
      Huashia Hotel(China)
    • Year and Date
      2011-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞の時空間ダイナミクス計測 : ライブセルイメージングから細胞骨格の力学バランスと細胞が発生する力をみる2011

    • Author(s)
      水谷武臣
    • Organizer
      九州大学共同利用研究会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Imaging for Cellular Mechanics: Dynamic Behavior of Cytoskeletal Networks and Cellular Contractile Force2011

    • Author(s)
      Takeomi Mizutani
    • Organizer
      The Fifth Shanghai International Conference on Biophysics and Molecular Biology(招待講演)
    • Place of Presentation
      Huashia Hotel (China)
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞の時空間ダイナミクス計測:ライブセルイメージングから細胞骨格の力学バランスと細胞が発生する力をみる2011

    • Author(s)
      水谷武臣
    • Organizer
      九州大学共同利用研究会
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://altair.sci.hokudai.ac.jp/g3/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] http://altair.sci.hokudai.ac.jp/g3/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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