| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Mast cells are involved in allergic responses. Antigen stimulation causes elevation of intracellular Ca2+ concentration, which triggers exocytotic release of inflammatory mediators. Therefore, it is important for the development of new anti-allergic drugs to elucidate the mechanism of exocytosis. In this study, we found that in addition to Ca2+, synaptotagmin2, which is a Ca2+ sensor for mast cell exocytosis enhanced exocytotic membrane fusion mediated by phosphatidylserine. These results indicated that not only proteins and Ca2+ but phospholipid are involved in mast cellexocytosis.
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