| Project/Area Number |
23770187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Nagahama Institute of Bio-Science and Technology |
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Principal Investigator |
SHIONYU Masafumi 長浜バイオ大学, バイオサイエンス学部, 講師 (30345847)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | バイオインフォマティクス / 選択的スプライシング / 機能予測 / 立体構造予測データベース / 次世代シーケンサ / プロテオミクス / 立体構造予測 / データベース / 次世代シーケンサー / 理論生物学 |
|---|
| Research Abstract |
Although many kinds of splicing isoforms are produced by alternative splicing, splicing isoforms whose functions are investigated are much fewer than all known sequence data of splicing isoforms. Therefore, I developed a pipeline that can estimate a functional significance of splicing isoforms. Using the pipeline, I estimated the functional significance of splicing isoforms that lost their parts important for forming hydrophobic core and seemed not to be stable. As a result, it is suggested that about 20% of such splicing isoform are functionally significant.
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