A study on ion-channel gating by single molecule measurement and manipulation.
| Project/Area Number |
23770190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HIRANO Minako 独立行政法人理化学研究所, 細胞動態計測研究グループ, 客員研究員 (80585167)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 分子計測 / イオンチャネル / 蛍光色素 / 1分子計測 / イメージング |
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| Research Abstract |
Using environment-sensitive fluorophore, conformational changes of a single ion channel were clearly detected. And, to clarify the relationship between conformational and functional changes of an ion channel, I improved an apparatus to measure these changes simultaneously at the single channel level. Using this apparatus, functional changes were easily detected and fluorescence images of a single ion channel were stably obtained.
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Report
(3 results)
Research Products
(19 results)
