| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We have analyzed two major of aberrant mRNAs, stop codon-less mRNA and nonsense-containing mRNA, to reveal the mechanism of the aberrant translation recognition and stimulation of aberrant products degradation. We found that mechanism of stop codon-less mRNA degradation by Dom34:Hbs1 complex. We also found that the mis-folded conformation of PTC products is important for leading to its degradation by Upf factors.
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