Mechanism of protein synthesis in mammalian mitochondria
| Project/Area Number |
23770202
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOMITA Nono (TAKEUCHI Nono) 東京大学, 大学院・新領域創成科学研究科, 准教授 (80323450)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 蛋白質合成 / ミトコンドリア / タンパク質合成 |
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| Research Abstract |
We have obtained following results on the mechanism of protein synthesis in mammalian mitochondrial. (1) The role of GTP-hydrolysis during ribosome recycling process has been clarified. (2) The sturucture of 55S ribosome has been determined at 10 A resolution by cryoEM reconstitution. The E-site tRNA on 55S ribosome has been visualized. (3) The ribosome binding properties of the mitochondrial ribosome biogenesis factor (ObgH1, Mtg1) have been clarified.
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Report
(3 results)
Research Products
(14 results)
