| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Polyubiquitination is the formation of an ubiquitin chain by the binding of ubiquitin molecules to a target protein. Polyubiquitin chains linked through different Lysine residues have different functions in the target proteins. In this study, I developed the method for purification of Lys63 (K63)-linked polyubiquitinated proteins from cell lysate. Furthermore, I demonstrated that K63-linked polyubiquitination is involved in the development of adult T-cell leukemia (ATL), which is caused by infection with HTLV-1, through regulation of NF-kB activation by viral protein, Tax.
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