The epigenetic roles of DNA damage repair in euchromatin

Research Project

Project/Area Number	23770205
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Molecular biology
Research Institution	Kyoto University
Principal Investigator	TSUBOTA Toshiaki 京都大学, 大学院・医学研究科, 助教 (40538138)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	エピジェネティクス / DNA修復 / ヒストン修飾 / ヒストンメチル化 / ヒストンアセチル化
Research Abstract	It has been reported that the efficient DNA damage response in heterochromatin requires histone H3 K9 methylation. However, in this study, it issuggested that H3 K9 methylation is not required for damage response signaling in euchromatin. Furthermore, the other histone modification is indicated to be involved in this regulation.

Report

(3 results)