Analysis of maturation process of endo -siRNA precursor
| Project/Area Number |
23770210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Niigata University |
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Principal Investigator |
MIYOSHI Tomohiro 新潟大学, 研究推進機構超域学術院, 助教 (60534550)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | RNA / siRNA / 小分子RNA / RNAサイレンシング / non-coding RNA / miRNA / プロセシング / Dicer |
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| Research Abstract |
Non-coding small RNAs act as functional molecules in cells. Endogenous siRNA (endo-siRNA) isone of the small RNAs, but its biosynthesis process is unknown. In this study, we succeeded indetection of endo-siRNA precursor present in the cell. Further, we showed that novel cytoplasmic fociare functionally important in the endo-siRNA biosynthesis. Furthermore, we identified novel proteinrelated to the biosynthesis mechanism of endo-siRNA.
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Report
(3 results)
Research Products
(15 results)
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[Presentation] Construction of in vitro Translation Elongation System with Archaeal Elongation Factors and Hybrid Ribosomes: Control of Interaction aEF-1A and Stalk aP1 by aEF-1B2012
Author(s)
Suzuki, T., Honda, T., Sato, S., Miyoshi, T., Ito, k., Uchiumi,. T.
Organizer
日本分子生物学会
Place of Presentation
福岡国際会議場、マリンメッセ福岡（福岡市）
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