| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The regulation of protein transport into endoplasmic reticulum and protein quality control in endoplasmic reticulum is important for the biosynthesis of the membrane and secretory proteins. In this study, we analyzed the functions of Kin1and Kin2 in protein transport and quality control using as a budding yeast as a model system. As a result, we demonstrated that Kin1 and Kin2 function in ER stress response in parallel with the Ire1-Hac1 pathway and in a manner dependent on their kinase activities.In addition, we identified 11 factors that it was expected to function around Kin1 andKin2 by genetic screening.
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