| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The TORC1 signaling plays a crucial role in a large number of cellular processes in response to nutrient signals. In this study, we investigated molecular mechanism of the nutrient-dependent TORC1 signaling in the fission yeast Schizosaccharomyces pombeand demonstrated three protein kinases as its substrates. Of these, it was especially revealed how Psk1 is regulated by TORC1 responding to nutrient availability. The findings obtained from this study indicate a milestone to elucidate the universal mechanism of cellular regulation by TORC1 signaling among eukaryotes.
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