Regulatory mechanism of TOR signaling in response to glucose
| Project/Area Number |
23770230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
TATEBE Hisashi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (00596819)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 分裂酵母 / TORC2 / Akt / Gタンパク質 / Ｇタンパク質 / 国際情報交流 |
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| Research Abstract |
The TORC2 - Akt pathway is evolutionarily conserved from yeast to human. Whereas the human TORC2 pathway responds to glucose via insulin stimuli, the TORC2 pathway in a unicellular organism fission yeast directly recognizes glucose in the extracellular environment, although precise molecular mechanism how the TORC2 pathway is activated upon insulin stimuli or glucose in those organisms has remained elusive. In this study, we utilized fission yeast as a model organism and revealed that activity of Ryh1, a known activator of TORC2, is regulated in response to glucose.
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Report
(3 results)
Research Products
(6 results)
