Mechanism of heterochromat i n formation during early mouse development
| Project/Area Number |
23770235
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
HIRATANI Ichiro 国立遺伝学研究所, 構造遺伝学研究センター, 助教 (40583753)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 核構造 / クロマチン / 生物・生体工学 / ゲノム / 遺伝子 / 発生・分化 |
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| Research Abstract |
Earlier studies suggested that an extensive heterochromatin formation takes place throughout the genome in post-implantation mouse embryos (heterochromatin: condensed chromosome regions with transcriptionally inactive genes). To explore its significance, we set out to identify genes involved in this heterochromatinization process. A list of candidate genes was generated and we asked whether suppression of any of these candidate genes could disrupt heterochromatin formation. This led to the identification of four novel genes involved in this process.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Chromosome engineering allows the efficient isolation of vertebrate neocentromeres2013
Author(s)
Shang WH, Hori T, Martins NM, Toyoda A, Misu S, Monma N, Hiratani I, Maeshima K, Ikeo K, Fujiyama A, Kimura H, Earnshaw WC, and Fukagawa T
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Journal Title
Dev Cell
Volume: 24
Issue: 6
Pages: 635-648
DOI
Related Report
Peer Reviewed
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