| Project/Area Number |
23770236
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
WADA Ken-ichi 独立行政法人理化学研究所, 前田バイオ工学研究室, 協力研究員 (20525919)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | Hippo シグナル経路 / 細胞増殖の接触阻止 / 微細加工技術 / 細胞の形 / F-actin / Hippoシグナル経路 / Yap / マイクロドメイン / cell shape / microdomain cell culture / Hippo signal / stress fiber/F-actin / contact inhibition |
|---|
| Research Abstract |
In this study, using microdomain cell culture system we investigated molecular mechanism of regulation for cell proliferation by cell morphology via Hippo signaling pathway. We found that cell morphology regulates stress fiber formation and it works as a negative regulator for Hippo signaling pathway. Based on these findings, we proposed a novel model for “contact inhibition of cell proliferation”, in which cell morphology acts as an initial trigger for the regulation for cell proliferation via Hippo signaling pathway by modulation of stress fiber formation.
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