Study on the mechanisms of mitochondrial maintenance by cooperation of proteolysis machineries
| Project/Area Number |
23770239
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | 沖縄科学技術大学院大学 |
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Principal Investigator |
TAKEDA Kojiro 沖縄科学技術大学院大学, グループリーダー (90426578)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞 / 蛋白質 / ミトコンドリア / 蛋白質分解 / 寿命 / タンパク質分解 / プロテアソーム / 細胞周期 / G0期 |
|---|
| Research Abstract |
In order to identify proteolysis factors, which are involved in maintaining mitochondrial quality, genetic screening was carried out, using Schizosaccharomyces pombe as a model organism. As a result, one potential E3 ubiquitin ligase (RING finger type) was identified to be required for mitochondrial morphology, mitophagy, and maintenance of life span of S.pombe cells in G0/quiescent phase.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut82011
Author(s)
Takeda, K., Tonthat, N., Glover, T., Xu, W., Koonin, E., Yanagida, M., and Schumacher, M
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 16950-16955
Related Report
Peer Reviewed
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[Journal Article] Mis17 is a regulatory models of the Mis6-Mal2-Sim4 centromere complexthat is required for the recruitment of CenH3/CENP-Ain fissionyeast2011
Author(s)
Shiroiwa, Y., Hayashi, T., Fujita, Y., Villar-Briones, A., Ikai, N., Takeda, K., Ebe, M., and Yanagida,M.
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Journal Title
Related Report
Peer Reviewed
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