| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The aim of this study is to understand the molecular mechanisms that determine the size of neurogenic ectoderm of the sea urchin embryos, especially focusing on the molecular interaction between signaling pathways that specify the cell fate along with the primary and secondary body axes. By loss-of-function experiments for each molecules, I could show that Wnt-JNK and Nodal pathways that are important to form primary and secondary axes, respectively, are essential for sea urchin embryos to maintain the precise size of anterior neurogenic ectoderm.
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