Molecular basis for maintenance of spermatogenic stem cells in themammalian testis
| Project/Area Number |
23770245
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 幹細胞 / 生殖細胞 / 精子 |
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| Research Abstract |
Spermatogenic stem cells ensure continuous spermatogenesis in the mammalian testis. However, mechanisms to regulate stemness of spermatogenic stem cells remain largely unknown. In this study, I developed a method for isolation of a small population containing spermatogenic stem cells and screened for genes that are specifically expressed in the stem cells. Some genes exhibited highly specific expression in stem cell fraction. To elucidate roles of these genes under a physiological condition of spermatogenesis, floxed mice of these genes have been generated. Now I am investigating their functions using the conditional knockout mice. Elucidation of functions of these genes will lead to a detailed understanding of molecular basis for maintenance of spermatogenic stem cells in mammalian.
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Report
(3 results)
Research Products
(1 results)
