Research of transcriptional repression mechanism by histone acetylation in the maintenance of cell fate
Project/Area Number |
23770257
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
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Research Institution | Kwansei Gakuin University |
Principal Investigator |
SHIBATA Yukimasa 関西学院大学, 理工学研究科, 博士研究員 (80314053)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | クロマチン / BET / 細胞運命維持 / UTX / H2A.z / アセチル化 / 細胞運命の維持 |
Research Abstract |
Histone acetylation is required for the maintenance of cell fates. But, its molecular mechanism is largely unknown. In this study, we investigate the dynamics of chromatin status that regulate cell-fate maintenance. As a results, we found that acetylated histone recruit histone variant HTZ-1/H2A.z on the loci that encodes transcription factor, and repress the locus. The recruitment of HTZ-1 is inhibited by H3K27me. We also found that the CeBAF complex that control histone deposition is required for the maintenance of cell fates.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans.2014
Author(s)
Kim H-S, Kitano Y, Mori M, Takano T, Harbaugh TE, Mizutani K, Yanagimoto H, Miwa S, Ihara S, Kubota Y, Shibata Y, Ikenishi K, Garriga G and Nishiwaki K.
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Journal Title
Genetics
Volume: 196(2)
Issue: 2
Pages: 471-479
DOI
URL
Related Report
Peer Reviewed / Open Access
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