relative size regulation in the developing organism

• Project/Area Number: 23770258
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: National Institute of Genetics
• Principal Investigator: HAYASHI Takashi 国立遺伝学研究所, 系統生物研究センター, 特任研究員 (50553765)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ショウジョウバエ / 相対成長 / yki / bantam / idgf / RNAi / IDGF / 増殖 / サイズ / insulin / IGF / micro RNA / yorkie / microRNA / dachshund

Outline of Final Research Achievements

We studied the mechanism of relative growth of organisms. In particular, we focused on (i) the identification of new factors that interact with the universal growth-regulating transcription factor Yki, (ii) construction of systems that quantify the strength of the activities of the growth-controlling microRNA bantam and the insulin / IGF signals in tissues and (iii) the functional study of imaginal disc growth factors (IDGFs), which are supposed to interact with the insulin / insulin-like growth factors and regulate imaginal disc proliferation.