The molecular mechanism for the regulation of neural stem cell proliferation in Drosophila

Research Project

Project/Area Number	23770262
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Developmental biology
Research Institution	公益財団法人大阪バイオサイエンス研究所 (2012) Osaka Bioscience Institute (2011)
Principal Investigator	KANAI Makoto 公益財団法人大阪バイオサイエンス研究所, 神経生物学部門, 研究員 (50598034)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	神経幹細胞 / ショウジョウバエ / グリア細胞 / ニッチ / HSPG / TGFβ
Research Abstract	Stemness is largely defined by neighboring tissues and cells called niche. To determine the contribution of glial cell niche for the proliferation of neural stem cell, I used Drosophila neuroblast as a model and found that glial cells and neuroblasts are in physical contact, on which they interact to regulate neuroblast proliferation with the distinct molecules that are mutually expressed on the each cell surface.

Report

(3 results)