Elucidation of mechanisms underlying neural circuit remodeling triggered by basement membrane degradation
| Project/Area Number |
23770263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | 公益財団法人大阪バイオサイエンス研究所 (2012)
Osaka Bioscience Institute (2011) |
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Principal Investigator |
YASUNAGA Kei-ichiro 公益財団法人大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (20534572)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 樹状突起再配置 / 細胞外マトリックス / 基底膜 / マトリックス・メタロプロテアーゼファミリー / 生体イメージング / 感覚神経 / ショウジョウバエ / 細胞外プロテアーゼ / MMPファミリー / 樹状突起 / 再編 / 細胞外基質 / プロテアーゼ |
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| Research Abstract |
In this study, we utilized in vivo imaging techniques and Drosophila molecular genetics to address molecular and cellular mechanisms underlying dendrite remodeling triggered by degradation of basement membranes, and found that spatial distributions of basement membranes correlated with dendritic branch behaviors during the dendrite remodeling.
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Report
(3 results)
Research Products
(13 results)
