Elucidation of mechanisms underlying neural circuit remodeling triggered by basement membrane degradation

• Project/Area Number: 23770263
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: 公益財団法人大阪バイオサイエンス研究所 (2012); Osaka Bioscience Institute (2011)
• Principal Investigator: YASUNAGA Kei-ichiro 公益財団法人大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (20534572)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 樹状突起再配置 / 細胞外マトリックス / 基底膜 / マトリックス・メタロプロテアーゼファミリー / 生体イメージング / 感覚神経 / ショウジョウバエ / 細胞外プロテアーゼ / MMPファミリー / 樹状突起 / 再編 / 細胞外基質 / プロテアーゼ

Research Abstract

In this study, we utilized in vivo imaging techniques and Drosophila molecular genetics to address molecular and cellular mechanisms underlying dendrite remodeling triggered by degradation of basement membranes, and found that spatial distributions of basement membranes correlated with dendritic branch behaviors during the dendrite remodeling.

Research Products

• [Journal Article] Compartmentalized Calcium Transients Trigger Dendrite Pruning in Drosophila Sensory Neurons (2013)
  • Author(s): Takahiro Kanamori, Makoto I. Kanai, Yusuke Dairyo, Kei-ichiro Yasunaga, Rei K. Morikawa, and Kazuo Emoto
  • Journal Title: Science Volume: 340 Issue: 6139 Pages: 1475-1478
  • DOI: 10.1126/science.1234879
  • Peer Reviewed
• [Journal Article] Select interneuron clusters determine female sexual receptivity in Drosophila. (2013)
  • Author(s): Sakurai, A., Koganezawa, M., Yasunaga, K., Emoto, K. and Yamamoto, D.
  • Journal Title: Nat. Commun. Volume: 4 Issue: 1 Pages: 1825-1833
  • DOI: 10.1038/ncomms2837
  • Peer Reviewed
• [Journal Article] Neural functions of matrix metalloproteinases: plasticity, neurogenesis, and disease. (2012)
  • Author(s): Fujioka H
  • Journal Title: Biochemistry Research International Volume: Volume 2012 Pages: 1-8
  • DOI: 10.1155/2012/789083
  • Peer Reviewed
• [Journal Article] Different levels of the tripartite motif protein Asap regulate distinct axonal projections of Drosophila sensory neurons (2011)
  • Author(s): Morikawa, et al
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Issue: 48 Pages: 19389-19394
  • DOI: 10.1073/pnas.1109843108
  • Peer Reviewed
• [Journal Article] Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons. (2011)
  • Author(s): Rei K. Morikawa
  • Journal Title: Proceedings of the National Academy of Sciences USA Volume: 108 Pages: 19389-19394
  • Peer Reviewed
• [Presentation] Adult and larval sensory neurons use different mechanisms to specify dendritic fields (2012)
  • Author(s): Kei-ichiro Yasunaga, Kazuo Emoto
  • Organizer: Joint Meeting of JSDB 45th & JSCB 64th
  • Place of Presentation: 神戸
• [Presentation] Adult and larval sensory neurons use different mechanisms to specify dendritic fields. (2012)
  • Author(s): Yasunaga K
  • Organizer: Joint Meeting of JSDB 45th & JSCB 64th
  • Place of Presentation: 神戸国際会議場
• [Presentation] Dendrite Remodeling in Adult Drosophila Sensory Neurons (2011)
  • Author(s): Kei-ichiro Yasunaga, Kazuo Emoto
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-05-24
• [Presentation] Dendrite Remodeling in Adult Drosophila Sensory Neurons (2011)
  • Author(s): Kei-ichiro Yasunaga
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Taiwan
• [Book] The Role of Matrix Metalloproteinases in Neural Plasticity and Disease." Matrix Metalloproteinases: Biology, Functions and Clinical Implications (2012)
  • Author(s): Kei-ichiro Yasunaga, Kazuo Emoto
  • Publisher: NOVA Publishers
• [Book] The Role of Matrix Metalloproteinases in Neural Plasticity and Disease. (2012)
  • Author(s): Yasunaga K
  • Total Pages: 10
  • Publisher: NOVA Publishers
• [Remarks]
  • URL: http://www.obi.or.jp/emoto-lab/research/
• [Remarks] OBI榎本研究室ホームページ
  • URL: http://www.obi.or.jp/emoto-lab/