| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
RhBG-like, RHBG-like2, and RhCG were obtained from brown hagfish species (Cyclostomata). RhCG and RhBG were determined from Red stingray and Japanese bullhead shark species (Condrichthyes), respectively. A phylogenetic tree shows that RhCG-like of brown hagfish formed a cluster with other vertebrate RhCG, though two RhBG-like genes were located on the common ancestral branch of vertebrate RhBG and RhCG. This is probably due to convergent amino acid substitutions occurred on RhBG-like genes of brown hagfish. During the evolution of the RH blood group gene family in vertebrates, the common ancestral gene of RH and RHAG, and the common ancestral gene of RHBG and RHCG had diverged by the first round of whole genome duplication. It is hypothesized that the former gene had begun to express erythrocytes in addition to original tissue, while the latter gene had kept expression in original tissue.
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