Analysis of the genome evolution by gene duplication using olfactory receptor gene families
| Project/Area Number |
23770271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | The University of Tokyo (2013-2015)
Tokyo Medical and Dental University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 嗅覚受容体 / 化学感覚 / 遺伝子ファミリー / 比較ゲノム / 分子進化 / 哺乳類の進化 / 化学受容 / 哺乳類 / 遺伝子クラスター / 多重遺伝子族 / カメ / ネットワーク |
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| Outline of Final Research Achievements |
Olfaction is essential for the survival of many animals. The ability to distinguish different odors depends on the number and type of olfactory receptors (ORs) present in each organism’s genome. In this project, we examined the OR genes encoded in 13 mammalian species’ genomes and found that African elephants have a surprisingly large number of OR genes, with approximately 2,000. This number is by far the largest among ever characterized. We also invented a novel bioinformatic method to trace the evolutionary trajectories of individual OR genes, and examined their duplications and losses in each species. We then discovered three OR genes that are evolutionarily stable for 100 million years without any duplications and losses and with very little change in sequence. Suggestively, these receptors would have physiologically important functions common to every mammal beyond the detection of odors.
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Report
(6 results)
Research Products
(50 results)
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[Journal Article] The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan.2013
Author(s)
Wang, Z., Pascual-Anaya, J., Zadissa, A., Li, W., Niimura, Y., Huang, Z., Li, C., White, S., Xiong, Z., Fang, D., et al.
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Journal Title
Nature genetics
Volume: 45
Issue: 6
Pages: 701-706
DOI
Related Report
Peer Reviewed / Open Access
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