| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We previously revealed that a mutation inPhoU, a negative regulator of bacterial phosphate regulon, results in the elevated levels of polyphosphate (polyP) in cell. However, PhoU mutants were rapidly outgrownby revertant(s) that lost the ability to accumulate polyP. In this study, we analyzed the mechanisms that the revertants lost polyP-accumulating ability, and established a method to screen stable PhoU mutants. The discovery in this study would be applicable to the development of a phosphorus-recovering technology.
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