Identification and functional analysis of a novel transcription factor controlling the expression of cellulase genes in filamentous fungi
| Project/Area Number |
23780086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
TANI Tani 大阪府立大学, 生命環境科学研究科, 助教 (80405357)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Aspergillus aculeatus / セルラーゼ遺伝子発現制御 / セロビオース誘導 / ClbR / アグロバクテリウム形質転換 / 遺伝子発現制御 / バイオマス / バイオテクノロジー / 応用微生物 / キシラナーゼ遺伝子発現制御 |
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| Research Abstract |
We revealed that ClbR, namely cellobiose response regulator, controlled the expression of cellulase and xylanase genes induced by cellobiose and cellulose in Aspergillus aculeatus. ClbR always locates in nuclei and cooperatively controls the gene expression with ClbR2, paralog of ClbR in A. aculeatus. Furthermore, we enabled to sustainable overproduction of cellulase and xylanase by overexpressing the clbR gene in A. aculeatus.
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Report
(3 results)
Research Products
(22 results)
