Understanding the molecular mechanism of trans-translation
| Project/Area Number |
23780099
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied biochemistry
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
KURITA Daisuke 弘前大学, 農学生命科学部, 助教 (60552651)
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | リボソーム / tmRNA / SmpB / タンパク合成 / トランスレーション / 翻訳 / トランス・トランスレーション / EF-Tu |
|---|
| Outline of Final Research Achievements |
Ribosomes stalled at the 3’ end of a truncated mRNA lacking a stop codon are rescued by trans-translation mediated by tmRNA and a partner protein SmpB. We revealed how tmRNA and SmpB preferentially recognize stalled ribosomes and not actively translating ones.
|
Report
(5 results)
Research Products
(16 results)
