| Project/Area Number |
23780112
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology (2012-2013)
Tohoku University (2011) |
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Principal Investigator |
ENOMOTO Masaru 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 研究員 (90546342)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 天然有機化合物 / indole diterpine / paspalinine / lecanindole D / 全合成 / 構造活性相関 / thiersinine / 部分構造 / 構造活性相関研究 / nodulisporic acid / paspalicine / 殺虫活性 |
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| Research Abstract |
Indole diterpenes are known to possess intriguing biological activity such as insecticidal, mito-inhibitory, and anti-MRSA activities. Therefore, synthetic studies and chemical supply of these compounds could solve the mechanism of action and contribute to development of various biology such as chemical ecology, cell biology, medicinal science. But, it was difficult to synthesis this family of natural products due to their complex structures. In this study, we have developed an efficient method to construct the indole diterpine framework and achieved total synthesis of paspalinine, a tremorgenic alkaloid, and lecanindole D, a progesterone receptor agonist.
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