Development of Oligonucleotide Synthesis by using hydrophobicNano-Reaction System
Project/Area Number |
23780113
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
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Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
KIM Shokaku 東京農工大学, 大学院・農学研究院, 准教授 (90537127)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 合成核酸 / RNA / 液相法 / 可溶化 / 核酸合成 |
Research Abstract |
We have developed a highly efficient and practical method of liquid-phase synthesis of oligonucleotides by using hydrophobic nano-reaction system based on alkyl chain soluble support. Specifically, this approach provides a practical and reliable oligonucleotide synthetic methodology in the development of scaled-up, cost-effective chemical RNA synthesis. The dispersion property of the support was markedly improved by the structural change of the linker moiety and by selection of dispersion media, which enabled enhanced reactivity in the liquid-phase approach.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Tag-Assisted Liquid-Phase Peptide Synthesis Using Hydrophobic Benzyl Alcohols as Supports2013
Author(s)
Okada, Y.; Suzuki, H.; Nakae, T.; Fujita, S.; Abe, H.; Nagano, K.; Yamada, T.; Ebata, N.; Kim, S.; Chiba, K.
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Journal Title
Journal of Organic Chemistry
Volume: 78
Issue: 2
Pages: 320-327
DOI
Related Report
Peer Reviewed
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