| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We have developed a highly efficient and practical method of liquid-phase synthesis of oligonucleotides by using hydrophobic nano-reaction system based on alkyl chain soluble support. Specifically, this approach provides a practical and reliable oligonucleotide synthetic methodology in the development of scaled-up, cost-effective chemical RNA synthesis. The dispersion property of the support was markedly improved by the structural change of the linker moiety and by selection of dispersion media, which enabled enhanced reactivity in the liquid-phase approach.
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