Search for novel C35 terpene cyclases, genome mining and biosynthesis of unnatural natural products
Project/Area Number |
23780114
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
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Research Institution | Niigata University |
Principal Investigator |
SATO Tsutomu 新潟大学, 自然科学系, 准教授 (80334655)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | テルペノイド / テルペン / イソプレノイド / 生合成 / 酵素 / テルペン環化酵素 / マイコバクテリア / 枯草菌 |
Research Abstract |
We found novel terpen cyclase from Bacillus subtilis, and proposed that C35 terpene should be called sesquarterpene. We identified a novel acyclic sesterterpene/triterpene synthase from Bacillus clausii. We found first bifunctional terpene cyclase which cyclizes two class of terpenes in vivo. We also performed isolation of a novel sesquarterpene from Mycobacterium and biosynthesis of unnatural terpenoids.
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Report
(3 results)
Research Products
(46 results)
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[Presentation] 細菌由来のsesquarterpenes(C35テルペン):ユニークな生合成酵素の同定と新規天然物探索2011
Author(s)
佐藤努,星野紘子,吉田悟,滝沢和央,折戸悠梨子,高木亮輔,丹野瑞樹,工藤はなよ,小野恵梨,中島真美,星野力
Organizer
第53回天然有機化合物討論会
Place of Presentation
大阪国際交流センター
Year and Date
2011-09-28
Related Report
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