Stereoselective synthesis of nitrogen-containing polycyclic natural products using C-N axial chirality
| Project/Area Number |
23780115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKAZAKI Atsuo 名古屋大学, 生命農学研究科, 准教授 (00366428)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 軸不斉 / インドール / 多環式含窒素天然物 / 不斉合成 / 生理活性物質 |
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| Research Abstract |
Stereoselective synthesis of oxindoles having a C3-stereogenic center isdeveloped for the synthesis of nitrogen-containing polycyclic natural products. The C3-stereochemistry could be controlled by an axial chirality on the C-N bond of monosubstituted N-aryl oxindoles in the moderate to high diastereoselective manner. This method allows us to synthesize a variety of oxindoles having substituents which can be seen in polycyclic alkaloids. The aryl moiety on the obtained oxindoles could be removed under the mild conditions.
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Report
(3 results)
Research Products
(69 results)
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[Journal Article] Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen2012
Author(s)
Yuka Miyano, Senko Tsukuda, Ippei Sakimoto, Ryo Takeuchi, Satomi Shimura, Noriyuki Takahashi, Tomoe Kusayanagi, Yoichi Takakusagi, Mami Okado, Yuki Matsumoto, Kaori Takakusagi, Toshifumi Takeuchi, Shinji Kamisuki, Atsuo Nakazaki, Keisuke Ohta, Masahiko Miura, Kouji Kuramochi, Yoshiyuki Mizushina, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi
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Journal Title
Bioorg. Med. Chem
Volume: 20
Pages: 3985-3990
Related Report
Peer Reviewed
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[Journal Article] The antitumor agent doxorubicin binds to Fanconi anemia group F protein2012
Author(s)
Tomoe Kusayanagi, Senko Tsukuda, Satomi Shimura, Daisuke Manita, Kanako Iwakiri, Shinji Kamisuki, Yoichi Takakusagi, Toshifumi Takeuchi, Kouji Kuramochi, Atsuo Nakazaki, Kengo Sakaguchi, Susumu Kobayashi, Fumio Sugawara
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Journal Title
Bioorg. Med. Chem
Volume: 20
Pages: 6248-6255
Related Report
Peer Reviewed
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[Journal Article] Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen2012
Author(s)
Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K.
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Journal Title
Bioorg. Med. Chem.
Volume: 20
Issue: 13
Pages: 3985-3990
DOI
Related Report
Peer Reviewed
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[Journal Article] The antitumor agent doxorubicin binds to Fanconi anemia group F protein2012
Author(s)
Kusavanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F
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Journal Title
Bioorg. Med. Chem.
Volume: 20
Issue: 21
Pages: 6248-6255
DOI
Related Report
Peer Reviewed
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