Development and mechanism of action of rare sugar derivatives with antiproliferative effect
| Project/Area Number |
23780117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
YANAGITA Ryo 香川大学, 農学部, 助教 (10598121)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | がん / 白血病 / 希少糖 / D-allose / allose |
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| Research Abstract |
The objectives of this project is to develop superior derivatives of D-allose, a rare sugar showing antiproliferative effect against human cancer cell lines, and molecular probes for an analysis of its mechanism of action.
First, we examined the modification for the C-6 OH group of D-allose and found that D-allose C-6 ester with medium chain fatty acids showed about 30 times higher effect compared to D-allose against human leukemia MOLT-4F cell line.
Then, we evaluated the activity of D-allose derivatives with 5-membered furanose form, and found that 6-membered pyranose form might be important for the activity of D-allose esters. Finally, we synthesized cell-permeable prodrugs for monosaccharide 6-phosphate, which could be a lead for molecular probes for an analysis of the mechanism of action.
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Report
(4 results)
Research Products
(17 results)
